ANNxBBB is Australian network of researchers working with nanoparticles in brain research area. The blood–brain barrier (BBB) is a vital boundary between neural tissue and circulating blood that prevents unwanted species to penetrate and harm brain. Delivering nanoparticle across BBB for drug delivery or bio-imaging is a stern and constant challenge.
The goal of this network is to bring together researchers with diverse expertise on nanoparticles and brain to share information, address key problems, accomplish advances and achieve major impact in the field.
The blood brain barrier (BBB) is a dynamic tight cellular network that separates the brain from the circulatory system and protects the central nervous system (CNS) from potentially harmful chemicals while regulating transport of essential molecules and maintaining a stable environment. While it performs a very important function by protecting a healthy functioning of CNS and brain, it is essential to overcome as a part of therapeutic or diagnostic treatment during disease or injury. Despite multiple reports in literature, there is no compelling knowledge on specific strategies how to cross BBB using different types of nanoparticles? What are the major factors that will promote nanoparticles to penetrate BBB and target brain? Is there any correlation between sizes, shape or surface functionalisation of nanoparticles and ability to cross BBB?